Je bent nog aan het kijken naar een oude versie. Klik hier om dit te veranderen

Course on Toxicogenomics

 Aim of the course

 
In this course, an introduction will be provided on genomics technologies, i.e. gene expression profiling by microarray technologies, focussing on its application in toxicology.
 
Content of the course
 
During this course, participants will be familiarized with the theoretical and practical background of toxicogenomics. Through lectures in the mornings, knowledge will be provided about the basic principles of gene expression profiling by DNA microarrays, its technologies, the main approaches for statistical analyses and visualisation of microarray data, and its application in toxicology. In the afternoon, practical experience with the main data analyses approaches and applications will be provided by computer trainings and a discussion group meeting.
 
List of subjects
 
Basic principles of genomics
- Methods for gene expression profiling (one and two-colour arrays)
- Image analysis, quality control and data pre-processing
- Data analysis: statistical approaches and visualisations
- Data mining to understand biology
- Other technologies: proteomics and metabolomics
Applied toxicogenomics
- Unravelling toxic mechanisms
- Biomarkers for toxic effects
- Predictive toxicology
- Regulatory aspects
Practical trainings 
- Image analysis of two-dye arrays (feature extraction, quality control and diagnosis)
- Data analysis to identify differentially expressed genes and to classify toxicants by gene expression profiles (including clustering approaches and visualisations)
- Identification of affected pathways and processes
- Design your own microarray experiment
 
Attainment 
 
Following this course the participants should:
be familiarized with the theoretical and practical background of toxicogenomics, especially transcriptomics by DNA microarrays
have knowledge about the basic principles of gene expression profiling by DNA microarrays, especially:
o the various technologies and platforms
o the main approaches for statistical analyses and visualisations
o the various options for data mining in order to understand the biology
o the main application areas in toxicology (mechanistic, predictive, and epidemiological) 
have practical experience for initial data analysis/visualisation/mining approaches of microarrays
have basic knowledge about other ‘omics technologies
 
List of organisers
 
Dr. J.H.M. van Delft (UM), Dr. R. Stierum (TNO), Dr. M. Luijten (RIVM) and Dr. H. Vrieling (LUMC)
 
Duration: 1 week
 
Period: 27 February – 02 March, 2012
 
Fee: Euro 1,000.- (PhD students may apply for the reduced rate of € 250.=)
 
Location: Maastricht University, Department of Toxicogenomics, Maastricht, The Netherlands
 
Registration: Through the “Postgraduate Education in Toxicology” at http://www.toxcourses.nl