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Netherlands Toxicogenomics Centre

Brochure: Proefdiervrije testmethode


Current toxicological research concentrates on identifying hazards of chemical compounds and assessing risks of human exposure. These assessments are based on toxicological tests, most using animals as models for man. Despite decades of experience, this risk assessment is still hampered by uncertainties, such as extrapolation of data from animal to man and from short-term experiments in animals to long-term real-life exposure of man.

Toxicogenomics - the application of genomics-based technologies in toxicological research - may provide tools to tackle these uncertainties. It also offers the opportunity to develop tests that require fewer laboratory animals or cause them less inconvenience, and may eventually replace animal tests completely by in vitro assays using animal or human cells.

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